Issue 55, 2018, Issue in Progress
From the journal:

RSC Advances

Targeting HMGA protein inhibits retinoblastoma cell proliferation†

Akilandeswari Balachandran,‡a   Ajit Zambre,‡b   Jagjot Singh Kainth, ORCID logo be   Lakshmi Dhevi Nagarajha Selvan,c   Sowmya Parameswaran,d   Zahra Afrasiabi,e   Subramanian Krishnakumar,*acd   Raghuraman Kannan ORCID logo *bf  and  Anandhi Upendran*gh  

* Corresponding authors

a Department of Nanobiotechnology, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Chennai, India
E-mail: drkk@snmail.org, drkrishnakumar_2000@yahoo.com

b Department of Radiology, University of Missouri, Columbia, MO, USA
E-mail: kannanr@health.missouri.edu

c L&T Ocular Pathology Department, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Chennai, India

d Radheshyam Kanoi Stem Cell Laboratory, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Chennai, India

e Department of Life Sciences, Lincoln University, Jefferson City, MO, USA

f Department of Biological Engineering, University of Missouri, Columbia, MO, USA

g Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA

h Institute of Clinical and Translational Sciences (MU-iCATS), School of Medicine, University of Missouri, Columbia, MO, USA
E-mail: upendrana@health.missouri.edu

Abstract

We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells.

Graphical abstract: Targeting HMGA protein inhibits retinoblastoma cell proliferation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8RA06026F
Article type
Paper
Submitted
15 Jul 2018
Accepted
26 Aug 2018
First published
07 Sep 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 31510-31514

Permissions

Request permissions

Targeting HMGA protein inhibits retinoblastoma cell proliferation

A. Balachandran, A. Zambre, J. S. Kainth, L. D. Nagarajha Selvan, S. Parameswaran, Z. Afrasiabi, S. Krishnakumar, R. Kannan and A. Upendran, RSC Adv., 2018, 8, 31510 DOI: 10.1039/C8RA06026F

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements