Issue 48, 2018

Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling

Abstract

An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important β-CF3 pyridines, through the regioselective, sequential formation of two C–C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules.

Graphical abstract: Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling

Supplementary files

Article information

Article type
Edge Article
Submitted
06 Aug 2018
Accepted
02 Oct 2018
First published
02 Oct 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2018,9, 9012-9017

Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling

D. Chen, L. Xu, T. Long, S. Zhu, J. Yang and L. Chu, Chem. Sci., 2018, 9, 9012 DOI: 10.1039/C8SC03493A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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