Issue 7, 2019

Hydrogen peroxide as a hydride donor and reductant under biologically relevant conditions

Abstract

Some ruthenium–hydride complexes react with O2 to yield H2O2, therefore the principle of microscopic reversibility dictates that the reverse reaction is also possible, that H2O2 could transfer an H to a Ru complex. Mechanistic evidence is presented, using the Ru-catalyzed ABTS˙ reduction reaction as a probe, which suggests that a Ru–H intermediate is formed via deinsertion of O2 from H2O2 following coordination to Ru. This demonstration that H2O2 can function as an H donor and reductant under biologically-relevant conditions provides the proof-of-concept that H2O2 may function as a reductant in living systems, ranging from metalloenzyme-catalyzed reactions to cellular redox homeostasis, and that H2O2 may be viable as an environmentally-friendly reductant and H source in green catalysis.

Graphical abstract: Hydrogen peroxide as a hydride donor and reductant under biologically relevant conditions

Supplementary files

Article information

Article type
Edge Article
Submitted
05 Dec 2018
Accepted
07 Dec 2018
First published
14 Dec 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 2025-2033

Hydrogen peroxide as a hydride donor and reductant under biologically relevant conditions

Y. Htet, Z. Lu, S. A. Trauger and A. G. Tennyson, Chem. Sci., 2019, 10, 2025 DOI: 10.1039/C8SC05418E

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