Issue 1, 2020

Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

Abstract

Using a covalent chemical probe and X-ray crystallography coupled to nuclear magnetic resonance data, we elucidated the dynamic molecular basis of protein recognition between the carrier protein and adenylation domain in pyoluteorin biosynthesis. These findings reveal a unique binding mode, which contrasts previously solved carrier protein and partner protein interfaces.

Graphical abstract: Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

Supplementary files

Article information

Article type
Communication
Submitted
27 Dec 2019
Accepted
26 Feb 2020
First published
24 Mar 2020
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2020,1, 8-12

Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis

J. C. Corpuz, L. M. Podust, T. D. Davis, M. J. Jaremko and M. D. Burkart, RSC Chem. Biol., 2020, 1, 8 DOI: 10.1039/C9CB00015A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements