Issue 24, 2019

Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

Abstract

We report on a naphthalimide ratiometric fluorescent probe for the real-time sensing and imaging of pathogenic bacterial glucosyltransferases, which are associated with the development of dental caries. Using a high-throughput screening method, we identified that several natural polyphenols from green tea were GTFs inhibitors that could eventually lead to suitable oral treatments to prevent the development of dental caries.

Graphical abstract: Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

Supplementary files

Article information

Article type
Communication
Submitted
17 Jan 2019
Accepted
25 Feb 2019
First published
25 Feb 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 3548-3551

Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

L. Feng, Q. Yan, B. Zhang, X. Tian, C. Wang, Z. Yu, J. Cui, D. Guo, X. Ma and T. D. James, Chem. Commun., 2019, 55, 3548 DOI: 10.1039/C9CC00440H

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