Issue 79, 2019

A ruthenium-catalyzed free amine directed (5+1) annulation of anilines with olefins: diverse synthesis of phenanthridine derivatives

Abstract

A ruthenium(II)-catalyzed cross-ring (5+1) annulation between 2-aminobiphenyls and activated olefins is disclosed for succinct synthesis of valuable phenanthridine scaffolds. The protocol avails a common organic functional group, free amine, as a directing group and represents a unique combination of C–H activation/annulation/C–C bond cleavage cascade that bodes well in the production of bioactive alkaloids including trisphaeridine and bicolorine.

Graphical abstract: A ruthenium-catalyzed free amine directed (5+1) annulation of anilines with olefins: diverse synthesis of phenanthridine derivatives

Supplementary files

Article information

Article type
Communication
Submitted
23 Jul 2019
Accepted
08 Sep 2019
First published
09 Sep 2019

Chem. Commun., 2019,55, 11908-11911

A ruthenium-catalyzed free amine directed (5+1) annulation of anilines with olefins: diverse synthesis of phenanthridine derivatives

D. Chowdhury, S. Dana, A. Mandal and M. Baidya, Chem. Commun., 2019, 55, 11908 DOI: 10.1039/C9CC05717J

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