Issue 92, 2019

“Off–on” switching of intracellular singlet oxygen release under biocompatible conditions

Abstract

Precise spatiotemporal control of singlet oxygen generation is of immense importance considering its involvement in photodynamic therapy. In this work, we present a rational design for an endoperoxide which is highly stable at ambient temperatures yet, can rapidly be converted into a highly labile endoperoxide, thus releasing the “stored” singlet oxygen on demand. The “off–on” chemical switching from the stable to the labile form is accomplished by the reaction with fluoride ions. The potential utility of controlled singlet oxygen release was demonstrated in cell cultures.

Graphical abstract: “Off–on” switching of intracellular singlet oxygen release under biocompatible conditions

Supplementary files

Article information

Article type
Communication
Submitted
11 Aug 2019
Accepted
25 Sep 2019
First published
15 Oct 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2019,55, 13808-13811

“Off–on” switching of intracellular singlet oxygen release under biocompatible conditions

E. Ucar, D. Xi, O. Seven, C. Kaya, X. Peng, W. Sun and E. U. Akkaya, Chem. Commun., 2019, 55, 13808 DOI: 10.1039/C9CC06231A

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