Issue 83, 2019

Monitoring fast chemical processes by reaction-interrupted excitation transfer (ExTra) NMR spectroscopy

Abstract

NMR spectroscopy is generally used to investigate molecules under equilibrium conditions. Despite recent technological and methodogical developments to study on-going reactions, tracing the fate of individual atoms during an irreversible chemical reaction is still a challenging and elaborate task. Reaction-interrupted excitation transfer (ExTra) NMR provides a selective tracking of resonances from atoms, which undergo chemical conversion. We show that reactions triggered either by rapid mixing or by photo-excitation can be conveniently followed at a sub-second time scale using standard NMR equipment. In ExTra NMR we use the selectively inverted magnetization of a selected atom to follow its conversion in the course of a fast chemical reaction. The chemical reaction has to be started within the relaxation period of an initial inverting 180° pulse. The presented protocol provides a generally applicable NMR method for reaction monitoring.

Graphical abstract: Monitoring fast chemical processes by reaction-interrupted excitation transfer (ExTra) NMR spectroscopy

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
19 Aug 2019
Accepted
26 Sep 2019
First published
26 Sep 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 12575-12578

Monitoring fast chemical processes by reaction-interrupted excitation transfer (ExTra) NMR spectroscopy

G. E. Wagner, S. Tassoti, S. Glanzer, E. Stadler, R. Herges, G. Gescheidt and K. Zangger, Chem. Commun., 2019, 55, 12575 DOI: 10.1039/C9CC06427C

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