Issue 86, 2019

Site-selective modification of tryptophan and protein tryptophan residues through PdNP bionanohybrid-catalysed C–H activation in aqueous media

Abstract

Herein we report for the first time the site-selective C–H bond arylation of tryptophan and tryptophan residues in proteins in aqueous media at room temperature by using a PdNP bionanohybrid as a heterogeneous catalyst. The reaction proceeds using a stable aryldiazonium salt without a base.

Graphical abstract: Site-selective modification of tryptophan and protein tryptophan residues through PdNP bionanohybrid-catalysed C–H activation in aqueous media

Supplementary files

Article information

Article type
Communication
Submitted
06 Sep 2019
Accepted
03 Oct 2019
First published
03 Oct 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2019,55, 12928-12931

Site-selective modification of tryptophan and protein tryptophan residues through PdNP bionanohybrid-catalysed C–H activation in aqueous media

C. Perez-Rizquez, O. Abian and J. M. Palomo, Chem. Commun., 2019, 55, 12928 DOI: 10.1039/C9CC06971B

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