Issue 3, 2019

Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria

Abstract

Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as D/L diaminobutyric acid and D-allo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria.

Graphical abstract: Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria

Supplementary files

Article information

Article type
Research Article
Submitted
17 Jan 2019
Accepted
20 Feb 2019
First published
12 Mar 2019
This article is Open Access
Creative Commons BY license

Med. Chem. Commun., 2019,10, 484-487

Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria

R. D. Ballantine, C. E. McCallion, E. Nassour, S. Tokajian and S. A. Cochrane, Med. Chem. Commun., 2019, 10, 484 DOI: 10.1039/C9MD00031C

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