Issue 44, 2019

Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

Abstract

Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between hydrophilic sugar pendant units and relatively hydrophobic polymer backbones can act as single-chain targeted nanocarriers for low molecular weight hydrophobic molecules. Non-covalent complexes formed from poly(triazolyl methacrylate) glycopolymers and low molecular weight hydrophobic guest molecules were characterised through a range of analytical techniques – DLS, SLS, TDA, fluorescence spectroscopy, surface tension analysis – and molecular dynamics (MD) modelling simulations provided further information on the macromolecular characteristics of these single chain complexes. Finally, we show that these nanocarriers can be utilised to deliver a hydrophobic guest molecule, Nile red, to both soluble and surface-immobilised concanavalin A (Con A) and peanut agglutinin (PNA) model lectins with high specificity, showing the potential of non-covalent complexation with specific glycopolymers in targeted guest-molecule delivery.

Graphical abstract: Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

Supplementary files

Article information

Article type
Paper
Submitted
09 Jul 2019
Accepted
28 Aug 2019
First published
29 Oct 2019
This article is Open Access
Creative Commons BY license

Nanoscale, 2019,11, 21155-21166

Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

J. Madeira do O, R. Foralosso, G. Yilmaz, F. Mastrotto, P. J. S. King, R. M. Xerri, Y. He, C. F. van der Walle, F. Fernandez-Trillo, C. A. Laughton, I. Styliari, S. Stolnik and G. Mantovani, Nanoscale, 2019, 11, 21155 DOI: 10.1039/C9NR05836B

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