Issue 1, 2020

Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity

Abstract

Eupulcherol A (1), a novel triterpenoid with an unprecedented carbon skeleton, was isolated from Euphorbia pulcherrima. Its structure was determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR, and the absolute configuration was defined by single crystal X-ray diffraction analysis. Biological studies showed that compound 1 possessed anti-Alzheimer's disease (AD) bioactivity, which could delay paralysis of transgenic AD Caenorhabditis elegans. A plausible biogenetic pathway for eupulcherol A (1) was also proposed.

Graphical abstract: Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity

Supplementary files

Article information

Article type
Paper
Submitted
29 Oct 2019
Accepted
18 Nov 2019
First published
19 Nov 2019

Org. Biomol. Chem., 2020,18, 76-80

Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity

C. Yu, R. Wang, F. Qi, P. Su, Y. Yu, B. Li, Y. Zhao, D. Zhi, Z. Zhang and D. Fei, Org. Biomol. Chem., 2020, 18, 76 DOI: 10.1039/C9OB02334H

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