Issue 2, 2020

Investigating the self-assembly and shape transformation of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) polymersomes by tailoring solvent-polymer interactions

Abstract

The assembly of amphiphilic block copolymers in well-defined polymer nanoparticles is an intricate interplay between polymer composition, method of assembly and the properties of the organic solvent used to dissolve the polymer building blocks. Remarkably, the role of organic solvent composition has been much less studied in comparison to the other two parameters. Here we have systematically investigated the effect of organic solvent composition, namely, the ratio between tetrahydrofuran and dioxane, on the self-assembly of PEG-PDLLA copolymers into polymer vesicles and their subsequent shape change in different topologies. Uncovering such physical basis unlocks new opportunities for the development of complex nanoparticles without the need of extended polymer engineering processes.

Graphical abstract: Investigating the self-assembly and shape transformation of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) polymersomes by tailoring solvent-polymer interactions

Supplementary files

Article information

Article type
Communication
Submitted
22 Jul 2019
Accepted
05 Sep 2019
First published
10 Sep 2019
This article is Open Access
Creative Commons BY-NC license

Polym. Chem., 2020,11, 275-280

Investigating the self-assembly and shape transformation of poly(ethylene glycol)-b-poly(D,L-lactide) (PEG-PDLLA) polymersomes by tailoring solvent-polymer interactions

I. A. B. Pijpers, F. Meng, J. C. M. van Hest and L. K. E. A. Abdelmohsen, Polym. Chem., 2020, 11, 275 DOI: 10.1039/C9PY01089K

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