Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells

Thitima Pewklang; Kantapat Chansaenpak; Rung-Yi Lai; Parinya Noisa; Anyanee Kamkaew

doi:10.1039/C9RA01948K

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Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells†

Thitima Pewklang,‡^a Kantapat Chansaenpak,‡^b Rung-Yi Lai,^a Parinya Noisa

^c and Anyanee Kamkaew

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand 30000
E-mail: anyanee@sut.ac.th

^b National Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, Thailand 12120

^c Laboratory of Cell-Based Assays and Innovations, School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima, Thailand 30000

Abstract

AZB-IMC₂ was developed as a COX-2 specific probe that exhibited a brighter fluorescence signal in cancer cells that overexpress COX-2 compared to normal cells. Oxidative stress agent-treated inflamed cell lines inducing high COX-2 levels revealed an enhanced fluorescence signal. Inhibitory studies showed a markedly reduced fluorescence intensity in cancer cells. The results suggested that AZB-IMC₂ could be developed as a promising molecular tool for imaging guiding during surgery.

This article is part of the themed collection: Editors' collection: Chemical Biology

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Article information

DOI: https://doi.org/10.1039/C9RA01948K
Article type: Paper
Submitted: 14 Mar 2019
Accepted: 26 Apr 2019
First published: 30 Apr 2019
This article is Open Access

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RSC Adv., 2019,9, 13372-13377

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Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells

T. Pewklang, K. Chansaenpak, R. Lai, P. Noisa and A. Kamkaew, RSC Adv., 2019, 9, 13372 DOI: 10.1039/C9RA01948K

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Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells†

Abstract

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Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells

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