Issue 18, 2019

Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

Abstract

Primary anilines are essential building blocks to synthesize various pharmaceuticals, agrochemicals, pigments, electronic materials, and others. To date, the syntheses of primary anilines mostly rely on the reduction of nitroarenes or the transition-metal-catalyzed Ullmann, Buchwald–Hartwig and Chan–Lam cross-coupling reactions with ammonia, in which non-renewable petroleum-based chemicals are typically used as feedstocks via multiple step syntheses. A long-standing scientific challenge is to synthesize various primary anilines directly from renewable sources. Herein, we report a general method to directly convert a broad range of phenols into the corresponding primary anilines with the cheap and widely available hydrazine as both amine and hydride sources with simple Pd/C as the catalyst.

Graphical abstract: Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

Supplementary files

Article information

Article type
Edge Article
Submitted
02 Feb 2019
Accepted
26 Mar 2019
First published
26 Mar 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 4775-4781

Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

Z. Qiu, L. Lv, J. Li, C. Li and C. Li, Chem. Sci., 2019, 10, 4775 DOI: 10.1039/C9SC00595A

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