Issue 44, 2019

Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

Abstract

A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium.

Graphical abstract: Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

Supplementary files

Article information

Article type
Edge Article
Submitted
17 Jun 2019
Accepted
19 Sep 2019
First published
19 Sep 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 10388-10394

Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

J. Fu, Z. Gu, Y. Liu, J. Zhang, H. Song, Y. Yang, Y. Yang, O. Noonan, J. Tang and C. Yu, Chem. Sci., 2019, 10, 10388 DOI: 10.1039/C9SC02961C

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