Issue 37, 2019

Canonical DNA minor groove insertion of bisbenzamidine–Ru(ii) complexes with chiral selectivity

Abstract

We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ-[Ru(bpy)2b4bpy]2+, Δ-4Ru) shows a considerably higher DNA affinity than the parent organic ligand and the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.

Graphical abstract: Canonical DNA minor groove insertion of bisbenzamidine–Ru(ii) complexes with chiral selectivity

Supplementary files

Article information

Article type
Edge Article
Submitted
20 Jun 2019
Accepted
30 Jul 2019
First published
01 Aug 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 8668-8674

Canonical DNA minor groove insertion of bisbenzamidine–Ru(II) complexes with chiral selectivity

M. I. Sánchez, G. Rama, R. Calo-Lapido, K. Ucar, P. Lincoln, M. V. López, M. Melle-Franco, J. L. Mascareñas and M. E. Vázquez, Chem. Sci., 2019, 10, 8668 DOI: 10.1039/C9SC03053K

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