Issue 5, 2020

Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties

Abstract

Herein, a versatile bilayer system, composed by a polypropylene (PP) mesh and a covalently bonded poly(N-isopropylacrylamide) (PNIPAAm) hydrogel, is reported. The cell adhesion mechanism was successfully modulated by controlling the architecture of the hydrogel in terms of duration of PNIPAAm grafting time, crosslinker content, and temperature of material exposure in PBS solutions (below and above the LCST of PNIPAAm). The best in vitro results with fibroblast (COS-1) and epithelial (MCF-7) cells was obtained with a mesh modified with a porous iPP-g-PNIPAAm bilayer system, prepared via PNIPAAm grafting for 2 h at the lowest N,N′-methylene bis(acrylamide) (MBA) concentration (1 mM). Under these conditions, the detachment of the fibroblast-like cells was 50% lower than that of the control, after 7 days of cell incubation, which represents a high de-adhesion of cells in a short period. Moreover, the whole system showed excellent stability in dry or wet media, proving that the thermosensitive hydrogel was well adhered to the polymer surface, after PP fibre activation by cold plasma. This study provides new insights on the development of anti-adherent meshes for abdominal hernia repair.

Graphical abstract: Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties

Supplementary files

Article information

Article type
Paper
Submitted
10 Nov 2019
Accepted
02 Jan 2020
First published
15 Jan 2020
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2020,8, 1049-1059

Polypropylene mesh for hernia repair with controllable cell adhesion/de-adhesion properties

S. Lanzalaco, L. J. Del Valle, P. Turon, C. Weis, F. Estrany, C. Alemán and E. Armelin, J. Mater. Chem. B, 2020, 8, 1049 DOI: 10.1039/C9TB02537E

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements