Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain

Lucas Schirmer; Chloé Hoornaert; Debbie Le Blon; Dimitri Eigel; Catia Neto; Mark Gumbleton; Petra B. Welzel; Anne E. Rosser; Carsten Werner; Peter Ponsaerts; Ben Newland

doi:10.1039/D0BM01249A

Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain†

Lucas Schirmer,^a Chloé Hoornaert,^b Debbie Le Blon,^bc Dimitri Eigel,^a Catia Neto,^d Mark Gumbleton,^d Petra B. Welzel,^a Anne E. Rosser,^ef Carsten Werner,

^ag Peter Ponsaerts^bc and Ben Newland

*^ad

Author affiliations

* Corresponding authors

^a Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069 Dresden, Germany
E-mail: newlandb@cardiff.ac.uk

^b Laboratory of Experimental Hematology, University of Antwerp, Antwerp, Belgium

^c Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium

^d School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK

^e Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, CF10 3AX Wales, UK

^f Neuroscience and Mental Health Institute and B.R.A.I.N unit. Cardiff University School of Medicine, Hadyn Ellis Building, Maindy Road, CF24 4HQ Cardiff, UK

^g Technische Universität Dresden, Center for Regenerative Therapies Dresden, Fetscherstr. 105, 01307 Dresden, Germany

Abstract

Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.

Biomaterials Science

Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain†

Abstract

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Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain

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