Issue 44, 2020
From the journal:

Chemical Communications

Generic high-capacity protein capture and release by pH control†

G. Ferrand-Drake del Castillo, ORCID logo a   R. L. N. Hailes,a   Z. Adali-Kaya,a   T. Robsona  and  Andreas Dahlin ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden
E-mail: adahlin@chalmers.se

Abstract

Techniques for immobilization and release of proteins are of general interest but challenging to develop. Here we show a new method for high-capacity (several μg cm−2) immobilization of proteins in polyelectrolyte brushes by multivalent hydrogen bonds. Upon increasing pH, the proteins are fully released with preserved structure and activity.

Graphical abstract: Generic high-capacity protein capture and release by pH control

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Article information

DOI
https://doi.org/10.1039/D0CC01250E
Article type
Communication
Submitted
17 Feb 2020
Accepted
28 Apr 2020
First published
29 Apr 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 5889-5892

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Generic high-capacity protein capture and release by pH control

G. Ferrand-Drake del Castillo, R. L. N. Hailes, Z. Adali-Kaya, T. Robson and A. Dahlin, Chem. Commun., 2020, 56, 5889 DOI: 10.1039/D0CC01250E

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