Issue 63, 2020

A short peptide that preferentially binds c-MYC G-quadruplex DNA

Abstract

G-quadruplexes (G4s) are non-canonical DNA secondary structures. The identification of selective tools to probe individual G4s over the ∼700 000 found in the human genome is key to unravel the biological significance of specific G4s. We took inspiration from a crystal structure of the bovine DHX36 helicase bound to the G4 formed in the promoter region of the oncogene c-MYC to identify a short peptide that preferentially binds MYC G4 with nM affinity over a small panel of parallel and non-parallel G4s tested.

Graphical abstract: A short peptide that preferentially binds c-MYC G-quadruplex DNA

Supplementary files

Article information

Article type
Communication
Submitted
23 Apr 2020
Accepted
01 Jul 2020
First published
01 Jul 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 8940-8943

A short peptide that preferentially binds c-MYC G-quadruplex DNA

A. Minard, D. Morgan, F. Raguseo, A. Di Porzio, D. Liano, A. G. Jamieson and M. Di Antonio, Chem. Commun., 2020, 56, 8940 DOI: 10.1039/D0CC02954H

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