SCHEDULED MAINTENANCE
Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades†
Ashley P.
Mattey, 
a
Lisa S.
Seibt,
a
William R.
Birmingham,
a
Nicholas J.
Turner
a
and
Sabine L.
Flitsch
*a
a
Lisa S.
Seibt,
a
William R.
Birmingham,
a
Nicholas J.
Turner
a
and
Sabine L.
Flitsch
*a
Abstract
Multi-enzyme cascades utilising variants of galactose oxidase and imine reductase led to the successful conversion of N-Cbz-protected L-ornithinol and L-lysinol to L-3-N-Cbz-aminopiperidine and L-3-N-Cbz-aminoazepane respectively, in up to 54% isolated yield. Streamlining the reactions into one-pot prevented potential racemisation of key labile intermediates and led to products with high enantiopurity.
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