Issue 68, 2020

Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?

Abstract

Deamidated amyloid proteins have been shown to accelerate fibril formation. Herein, the results show the inhibition performance and the interaction site between site-specific inhibitor and amyloid protein are significantly influenced by deamidation; while the inhibition mechanism of non-site specific inhibitor shows no significant disruption caused by amyloid protein deamidation.

Graphical abstract: Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?

Supplementary files

Article information

Article type
Communication
Submitted
18 May 2020
Accepted
21 Jul 2020
First published
30 Jul 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 9787-9790

Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?

Y. P. Y. Lam, C. K. C. Chiu, C. A. Wootton, I. Hands-Portman, M. Li, M. P. Barrow and P. B. O'Connor, Chem. Commun., 2020, 56, 9787 DOI: 10.1039/D0CC03548C

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