Issue 69, 2020

A matrix metalloproteinase activation probe for painting human tumours

Abstract

A probe that allows specific ‘painting’ of human tumours is described. Probe activation was mediated by specific matrix metalloproteinases, resulting not only in disruption of a FRET pair, but in the generation of a fragment that “fluorescently paints” human tumours. This probe demonstrated rapid and effective human tumour labelling with the potential to allow margin detection during surgical resection.

Graphical abstract: A matrix metalloproteinase activation probe for painting human tumours

Supplementary files

Article information

Article type
Communication
Submitted
03 Jun 2020
Accepted
14 Jul 2020
First published
16 Jul 2020
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2020,56, 9962-9965

A matrix metalloproteinase activation probe for painting human tumours

B. Mills, D. Norberg, K. Dhaliwal, A. R. Akram, M. Bradley and A. Megia-Fernandez, Chem. Commun., 2020, 56, 9962 DOI: 10.1039/D0CC03886E

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