Issue 24, 2021

A large, square-shaped, DNA origami nanopore with sealing function on a giant vesicle membrane

Abstract

Intaking molecular information from the external environment is essential for the normal functioning of artificial cells/molecular robots. Herein, we report the design and function of a membrane nanopore using a DNA origami square tube with a cross-section of 100 nm2. When the nanopore is added to a giant vesicle that mimics a cell membrane, the permeation of large external hydrophilic fluorescent molecules is observed. Furthermore, the addition of up to four ssDNA strands enables size-based selective transport of molecules. A controllable artificial nanopore should facilitate the communication between the vesicle components and their environment.

Graphical abstract: A large, square-shaped, DNA origami nanopore with sealing function on a giant vesicle membrane

Supplementary files

Article information

Article type
Communication
Submitted
11 Nov 2020
Accepted
01 Feb 2021
First published
01 Feb 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 2990-2993

A large, square-shaped, DNA origami nanopore with sealing function on a giant vesicle membrane

S. Iwabuchi, I. Kawamata, S. Murata and S. M. Nomura, Chem. Commun., 2021, 57, 2990 DOI: 10.1039/D0CC07412H

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