Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

Zoë Rachael Goddard; Andrew Michael Beekman; Marco M. D. Cominetti; Maria A. O'Connell; Isabelle Chambrier; Michael J. Cook; María J. Marín; David A. Russell; Mark Searcey

doi:10.1039/D0MD00284D

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Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers†

Zoë Rachael Goddard,

^a Andrew Michael Beekman,

^a Marco M. D. Cominetti,^a Maria A. O'Connell,

^a Isabelle Chambrier,^b Michael J. Cook,^b María J. Marín,

^b David A. Russell

^b and Mark Searcey

*^a

Author affiliations

* Corresponding authors

^a School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, UK
E-mail: M.Searcey@uea.ac.uk

^b School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, UK

Abstract

Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

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Article information

DOI: https://doi.org/10.1039/D0MD00284D
Article type: Research Article
Submitted: 08 Aug 2020
Accepted: 16 Nov 2020
First published: 19 Nov 2020
This article is Open Access

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RSC Med. Chem., 2021,12, 288-292

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Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

Z. R. Goddard, A. M. Beekman, M. M. D. Cominetti, M. A. O'Connell, I. Chambrier, M. J. Cook, M. J. Marín, D. A. Russell and M. Searcey, RSC Med. Chem., 2021, 12, 288 DOI: 10.1039/D0MD00284D

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RSC Medicinal Chemistry

Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers†

Abstract

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Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

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