Issue 27, 2020

An amide hydrogen bond templated [1]rotaxane displaying a peptide motif – demonstrating an expedient route to synthetic mimics of lasso peptides

Abstract

The rapid synthesis of an amide hydrogen bond templated [1]rotaxane is reported – demonstrating a potential pathway to synthetic analogues of lasso peptides. The structures of the [1]rotaxane and its unthreaded isomer have been characterized by NMR spectroscopy and modelled using DFT calculations.

Graphical abstract: An amide hydrogen bond templated [1]rotaxane displaying a peptide motif – demonstrating an expedient route to synthetic mimics of lasso peptides

Supplementary files

Article information

Article type
Paper
Submitted
09 Jun 2020
Accepted
23 Jun 2020
First published
24 Jun 2020
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2020,18, 5203-5209

An amide hydrogen bond templated [1]rotaxane displaying a peptide motif – demonstrating an expedient route to synthetic mimics of lasso peptides

M. J. Young, G. R. Akien and N. H. Evans, Org. Biomol. Chem., 2020, 18, 5203 DOI: 10.1039/D0OB01190H

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