Issue 28, 2020

Planar chiral palladacycle precatalysts for asymmetric synthesis

Abstract

Chiral non-racemic palladacycles were employed as precatalysts for Pd(0) mediated asymmetric synthesis. Addition of HPAr2/base to a ferrocenyloxazoline planar chiral palladacycle resulted in ligand synthesis and palladium capture to give a bidentate Phosferrox/Pd(0) complex. A series of these complexes were generated in situ and applied successfully as catalysts for asymmetric allylic alkylation.

Graphical abstract: Planar chiral palladacycle precatalysts for asymmetric synthesis

Supplementary files

Article information

Article type
Paper
Submitted
30 Apr 2020
Accepted
02 Jul 2020
First published
02 Jul 2020
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2020,18, 5466-5472

Planar chiral palladacycle precatalysts for asymmetric synthesis

R. A. Arthurs, D. L. Hughes and C. J. Richards, Org. Biomol. Chem., 2020, 18, 5466 DOI: 10.1039/D0OB01331E

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