Issue 40, 2020
From the journal:

RSC Advances

Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12†

Ping-Sheng Wu,a   Shu-Jung Lai,bd   Kit-Man Fungb  and  Tien-Sheng Tseng ORCID logo *c  

* Corresponding authors

a Division of Infectious Diseases, Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan

b Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan

c Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan

d Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan

Abstract

Antimicrobial peptides (AMPs) are potential candidates in designing new anti-infective agents. However, many AMPs show poor bactericidal activities in physical salt and serum solutions. Here, we disclosed the structure–function relationships of a novel salt-resistant antimicrobial peptide, RR12, which could further explain its mode of action and show its applicability in developing new antibacterial agents.

Graphical abstract: Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12

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Article information

DOI
https://doi.org/10.1039/D0RA04299D
Article type
Paper
Submitted
14 May 2020
Accepted
15 Jun 2020
First published
22 Jun 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 23624-23631

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Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12

P. Wu, S. Lai, K. Fung and T. Tseng, RSC Adv., 2020, 10, 23624 DOI: 10.1039/D0RA04299D

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