Issue 81, 2021

Dye-functionalized phosphate-binding macrocycles: from nucleotide to G-quadruplex recognition and “turn-on” fluorescence sensing

Abstract

A novel strategy to design “turn-on” fluorescent receptors for G-quadruplexes of DNA is presented, which relies on the connection of phosphate binding macrocycles (PBM) with naphthalimide dyes. A new PBM-dye family was synthesized and evaluated in terms of binding and detection of nucleotides and DNA G-quadruplexes of different topologies.

Graphical abstract: Dye-functionalized phosphate-binding macrocycles: from nucleotide to G-quadruplex recognition and “turn-on” fluorescence sensing

Supplementary files

Article information

Article type
Communication
Submitted
28 Jul 2021
Accepted
22 Sep 2021
First published
22 Sep 2021

Chem. Commun., 2021,57, 10632-10635

Dye-functionalized phosphate-binding macrocycles: from nucleotide to G-quadruplex recognition and “turn-on” fluorescence sensing

A. S. Oshchepkov, O. Reznichenko, D. Xu, B. S. Morozov, A. Granzhan and E. A. Kataev, Chem. Commun., 2021, 57, 10632 DOI: 10.1039/D1CC04096K

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