Issue 6, 2004
From the journal:

Chemical Communications

Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.†

Ian Paterson,a   Robert Britton,a   Oscar Delgadoa  and  Amy E. Wrightb  

a University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: ip100@cam.ac.uk
Fax: +44 1223 336362
Tel: +44 1223 336407

b Harbor Branch Oceanographic Institution, Fort Pierce, Florida, USA, 34946
E-mail: Wright@HBOI.edu
Fax: +1 772 461 2221
Tel: +1 772 465 2400

Abstract

The relative stereochemistry of the 22-membered marine macrolide dictyostatin, a Taxol-like antimitotic agent, was determined based on a combination of extensive high field NMR studies, including J-based configuration analysis, and molecular modelling.

Graphical abstract: Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.

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Article information

DOI
https://doi.org/10.1039/B316390C
Article type
Communication
Submitted
16 Dec 2003
Accepted
26 Jan 2004
First published
09 Feb 2004

Chem. Commun., 2004, 632-633

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Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.

I. Paterson, R. Britton, O. Delgado and A. E. Wright, Chem. Commun., 2004, 632 DOI: 10.1039/B316390C

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