Issue 28, 2005
From the journal:

Chemical Communications

Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support†

Ian Paterson,*a   Dirk Gottschlinga  and  Dirk Menchea  

* Corresponding authors

a University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: ip100@cam.ac.uk
Fax: +44 1223 336362
Tel: +44 1223 336407

Abstract

By relying on asymmetric boron-mediated aldol reactions, solid phase methodology for the stereoselective synthesis of highly substituted spiroacetals was developed and applied to the preparation of a complex AB-spiroacetal subunit of the antimitotic agent spongistatin 1 (altohyrtin A).

Graphical abstract: Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support

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Article information

DOI
https://doi.org/10.1039/B505746A
Article type
Communication
Submitted
26 Apr 2005
Accepted
03 Jun 2005
First published
15 Jun 2005

Chem. Commun., 2005, 3568-3570

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Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support

I. Paterson, D. Gottschling and D. Menche, Chem. Commun., 2005, 3568 DOI: 10.1039/B505746A

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