Issue 12, 2008

Primary amino acids: privileged catalysts in enantioselective organocatalysis

Abstract

Despite the recent spectacular advances in asymmetric organocatalysis, proline and its analogues have been predominantly employed as organocatalysts in reactions utilizing enamine intermediates. Recent studies of enantioselective organocatalytic reactions promoted by primary amino acids and their derivatives are described in this account. The primary amino functions, rather than the secondary pyrrolidine moiety, have been shown to provide unique reactivity and stereoselectivity in asymmetric aldol and Mannich reactions.

Graphical abstract: Primary amino acids: privileged catalysts in enantioselective organocatalysis

Article information

Article type
Emerging Area
Submitted
22 Feb 2008
Accepted
14 Mar 2008
First published
21 Apr 2008

Org. Biomol. Chem., 2008,6, 2047-2053

Primary amino acids: privileged catalysts in enantioselective organocatalysis

L. Xu and Y. Lu, Org. Biomol. Chem., 2008, 6, 2047 DOI: 10.1039/B803116A

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