Issue 21, 2009
From the journal:

Organic & Biomolecular Chemistry

Chiral biphenylamide derivative: an efficient organocatalyst for the enantioselective synthesis of α-hydroxy phosphonates†

Jun Jiang,a   Xiaohong Chen,a   Jun Wang,a   Yonghai Hui,a   Xiaohua Liu,a   Lili Lina  and  Xiaoming Feng*a  

* Corresponding authors

a Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
E-mail: xmfeng@scu.edu.cn
Fax: +86 28 85418249
Tel: +86 28 85418249

Abstract

The aldol reactions of α-keto phosphonates and aldehydes were facilitated by an axially chiral biphenylprolinamide under mild conditions, affording the synthetically and pharmaceutically useful products in high yields and excellent enantioselectivities.

Graphical abstract: Chiral biphenylamide derivative: an efficient organocatalyst for the enantioselective synthesis of α-hydroxy phosphonates

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Article information

DOI
https://doi.org/10.1039/B917554G
Article type
Communication
Submitted
25 Aug 2009
Accepted
04 Sep 2009
First published
17 Sep 2009

Org. Biomol. Chem., 2009,7, 4355-4357

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Chiral biphenylamide derivative: an efficient organocatalyst for the enantioselective synthesis of α-hydroxy phosphonates

J. Jiang, X. Chen, J. Wang, Y. Hui, X. Liu, L. Lin and X. Feng, Org. Biomol. Chem., 2009, 7, 4355 DOI: 10.1039/B917554G

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