Issue 1, 2009

Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays

Abstract

Perfectly aligned arrays of single-crystalline silicon nanowires were fabricated using top-down CMOS-compatible techniques. We demonstrate that these nanowire devices are able to detect adipocytokines secreted by adipose cells with femtomolar sensitivity, high specificity, wide detection range, and ability for parallel monitoring. The nanowire sensors also provide a novel tool to reveal the poorly understood signaling mechanisms of these newly recognized signaling molecules, as well as their relevance in common diseases such as obesity and diabetes.

Graphical abstract: Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays

Supplementary files

Article information

Article type
Feature Article
Submitted
03 May 2009
Accepted
27 Jun 2009
First published
13 Aug 2009

Nanoscale, 2009,1, 159-163

Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays

T. Pui, A. Agarwal, F. Ye, Z. Tou, Y. Huang and P. Chen, Nanoscale, 2009, 1, 159 DOI: 10.1039/B9NR00092E

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