Issue 6, 2011
From the journal:

Analyst

Evaluation of tip-enhanced Raman spectroscopy for characterizing different virus strains†

Peter Hermann,a   Antje Hermelink,a   Veronika Lausch,b   Gudrun Holland,b   Lars Möller,b   Norbert Bannertb  and  Dieter Naumann*a  

* Corresponding authors

a P25 – Biomedical Spectroscopy, Robert-Koch Institute, Nordufer 20, D-13353 Berlin, Germany
E-mail: NaumannD@rki.de
Fax: +49 30 18754 2606
Tel: +49 30 18754 2259

b ZBS4 – Center for biological Safety, Robert-Koch Institute, Nordufer 20, D-13353 Berlin, Germany

Abstract

Tip-enhanced Raman spectroscopy (TERS) is a highly sensitive spectroscopic technique which combines the advantages of optical spectroscopy with the requirements needed for the characterization of biological nano-structures. In this study, TERS was used to investigate the applicability of this spectroscopic technique for the detection of different virus strains like avipoxvirus and adeno-associated virus. TERS spectra obtained from different particles of the same virus strain show variations in relative peak intensities and positions of most spectral features observed. These spectral variations were higher for the larger avipoxvirus particles (∅ ≈ 350 nm) than for the smaller adeno-associated virus particles (∅ ≈ 26 nm).

Graphical abstract: Evaluation of tip-enhanced Raman spectroscopy for characterizing different virus strains

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Article information

DOI
https://doi.org/10.1039/C0AN00531B
Article type
Paper
Submitted
16 Jul 2010
Accepted
23 Dec 2010
First published
26 Jan 2011

Analyst, 2011,136, 1148-1152

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Evaluation of tip-enhanced Raman spectroscopy for characterizing different virus strains

P. Hermann, A. Hermelink, V. Lausch, G. Holland, L. Möller, N. Bannert and D. Naumann, Analyst, 2011, 136, 1148 DOI: 10.1039/C0AN00531B

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