Surface enhanced Raman evidence for Ag+ complexes of adenine, deoxyadenosine and 5′-dAMP formed in silver colloids

Evanthia Papadopoulou; Steven E. J. Bell

doi:10.1039/C0AN00612B

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Surface enhanced Raman evidence for Ag⁺ complexes of adenine, deoxyadenosine and 5′-dAMP formed in silver colloids†‡

Evanthia Papadopoulou^a and Steven E. J. Bell*^a

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* Corresponding authors

^a Innovative Molecular Materials Group, School of Chemistry and Chemical Engineering, Queen's University, Belfast, UK
E-mail: s.bell@qub.ac.uk
Fax: +44 (0)2890 976524
Tel: +44 (0)2890 974470

Abstract

We report the formation of highly scattering silver complexes of adenine, deoxyadenosine and 5′-dAMP under alkaline pH conditions in the colloidal silver solutions which are used for surface-enhanced Raman spectroscopy. These complexes, and other pH-dependent phenomena, help to explain the diversity of previously reported adenine SERS spectra. Using conditions which promote complex formation allows nucleotides to be detected at <1 ppm, even in solutions with high salt concentrations.

This article is part of the themed collection: Optical Diagnosis

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Supplementary files

Experimental methods, SERS spectra of adenine adsorbed on CRSC and gold colloid at pH 11 at the concentration range 0.01–10 ppm, blank sample SERS spectrum of HRSC on Ag ⁺ addition, normal Raman spectra of adenine, polycrystalline Cu(C ₅H ₄N ₅) ₂ and the SERS spectra of 0.25 ppm adenine on HRSC at pH 11, SERS spectra of adenine, adenosine, deoxyadenine, AMP and 5′-dAMP at low concentration on HRSC at pH 11 PDF (354K)

Article information

DOI: https://doi.org/10.1039/C0AN00612B
Article type: Communication
Submitted: 06 Aug 2010
Accepted: 14 Sep 2010
First published: 28 Sep 2010

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Analyst, 2010,135, 3034-3037

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Surface enhanced Raman evidence for Ag⁺ complexes of adenine, deoxyadenosine and 5′-dAMP formed in silver colloids

E. Papadopoulou and S. E. J. Bell, Analyst, 2010, 135, 3034 DOI: 10.1039/C0AN00612B

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