Issue 6, 2011
From the journal:

Chemical Communications

A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action†

Nicholas T. Salzameda,a   Lisa M. Eubanks,ab   Joseph S. Zakhari,a   Kyoji Tsuchikama,a   Nicholas J. DeNunzio,c   Karen N. Allen,c   Mark S. Hixond  and  Kim D. Janda*ab  

* Corresponding authors

a Departments of Chemistry, Immunology and Microbial Science, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, USA
E-mail: kdjanda@scripps.edu
Fax: +1 858 784-2595
Tel: +1 858 784-2516

b Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, USA

c Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, USA

d Discovery Biology, Takeda San Diego, Inc., 10410 Science Center Drive, San Diego, USA

Abstract

Clostridium botulinum produces the most lethal toxins known to man, as such they are high risk terrorist threats, and alarmingly there is no approved therapeutic. We report the first cross-over small molecule inhibitor of these neurotoxins and propose a mechanism by which it may impart its inhibitory activity.

Graphical abstract: A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action

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Article information

DOI
https://doi.org/10.1039/C0CC04078A
Article type
Communication
Submitted
26 Sep 2010
Accepted
06 Dec 2010
First published
04 Jan 2011

Chem. Commun., 2011,47, 1713-1715

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A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action

N. T. Salzameda, L. M. Eubanks, J. S. Zakhari, K. Tsuchikama, N. J. DeNunzio, K. N. Allen, M. S. Hixon and K. D. Janda, Chem. Commun., 2011, 47, 1713 DOI: 10.1039/C0CC04078A

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