Issue 7, 2011

A novel Zn-catalyzed hydroamination of propargylamides: a general synthesis of di- and tri-substituted imidazoles

Abstract

Starting from commercially available amines and propargylamides a variety of substituted imidazoles were synthesized via a novel hydroamination–cyclization sequence. The target compounds are obtained in good to excellent yields in the presence of catalytic amounts of zinc triflate.

Graphical abstract: A novel Zn-catalyzed hydroamination of propargylamides: a general synthesis of di- and tri-substituted imidazoles

Supplementary files

Article information

Article type
Communication
Submitted
26 Oct 2010
Accepted
07 Dec 2010
First published
04 Jan 2011

Chem. Commun., 2011,47, 2152-2154

A novel Zn-catalyzed hydroamination of propargylamides: a general synthesis of di- and tri-substituted imidazoles

A. Pews-Davtyan and M. Beller, Chem. Commun., 2011, 47, 2152 DOI: 10.1039/C0CC04625F

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