Issue 18, 2011

Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd–PEPPSI–IPent

Abstract

Pd–PEPPSI–IPent has proven to be an excellent catalyst for the Negishi cross-coupling reaction of secondary alkylzinc reagents with a wide variety of aryl/heteroaryl halides. Importantly, β-hydride elimination/migratory insertion of the organometallic leading to the production of isomeric coupling products has been significantly reduced using the highly-hindered Ipent ligand.

Graphical abstract: Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd–PEPPSI–IPent

Supplementary files

Article information

Article type
Communication
Submitted
07 Nov 2010
Accepted
14 Jan 2011
First published
01 Feb 2011

Chem. Commun., 2011,47, 5181-5183

Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd–PEPPSI–IPent

S. Çalimsiz and M. G. Organ, Chem. Commun., 2011, 47, 5181 DOI: 10.1039/C0CC04835F

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