Issue 6, 2011

Continuous biocatalytic synthesis of (R)-2-octanol with integrated product separation

Abstract

The continuous biocatalytic synthesis of (R)-2-octanol carried out in an enzyme membrane reactor showed an excellent process stability of the biocatalysts, resulting in a turnover number of 15 million for the applied alcohol dehydrogenase. Utilisation of the ionic liquid AMMOENG™ 101 as a feasible cosolvent increased substrate concentration, and improved space time yields and turnover numbers of the cofactor by factors of 3 and 6, respectively. Moreover, 80% less waste was generated, while producing the same amount of product. Integrated product separation was realized viasolid phase extraction. Extraction of the applied solid phase with supercritical carbon dioxide allowed more than 30 reuses of the solid phase.

Graphical abstract: Continuous biocatalytic synthesis of (R)-2-octanol with integrated product separation

Article information

Article type
Paper
Submitted
09 Nov 2010
Accepted
12 Jan 2011
First published
15 Feb 2011

Green Chem., 2011,13, 1430-1436

Continuous biocatalytic synthesis of (R)-2-octanol with integrated product separation

C. Kohlmann, S. Leuchs, L. Greiner and W. Leitner, Green Chem., 2011, 13, 1430 DOI: 10.1039/C0GC00790K

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