Issue 3, 2011

“On water”-promoted direct alkynylation of isatins catalyzed by NHC–silver complexes for the efficient synthesis of 3-hydroxy-3-ethynylindolin-2-ones

Abstract

The direct alkynylation of isatins catalyzed by NHC–Ag complexes via the activation of alkyne C–H bond on water was developed for the efficient synthesis of 3-hydroxy-3-ethynylindolin-2-ones under an air atmosphere. A remarkable rate-enhancement by water in the aqueous heterogeneous system was observed.

Graphical abstract: “On water”-promoted direct alkynylation of isatins catalyzed by NHC–silver complexes for the efficient synthesis of 3-hydroxy-3-ethynylindolin-2-ones

Supplementary files

Article information

Article type
Communication
Submitted
12 Nov 2010
Accepted
21 Dec 2010
First published
02 Feb 2011

Green Chem., 2011,13, 549-553

“On water”-promoted direct alkynylation of isatins catalyzed by NHC–silver complexes for the efficient synthesis of 3-hydroxy-3-ethynylindolin-2-ones

X. Fu, L. Liu, D. Wang, Y. Chen and C. Li, Green Chem., 2011, 13, 549 DOI: 10.1039/C0GC00807A

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