Issue 2, 2011

Multi-scale modelling and simulation in systems biology

Abstract

The aim of systems biology is to describe and understand biology at a global scale where biological functions are recognised as a result of complex mechanisms that happen at several scales, from the molecular to the ecosystem. Modelling and simulation are computational tools that are invaluable for description, prediction and understanding these mechanisms in a quantitative and integrative way. Therefore the study of biological functions is greatly aided by multi-scale methods that enable the coupling and simulation of models spanning several spatial and temporal scales. Various methods have been developed for solving multi-scale problems in many scientific disciplines, and are applicable to continuum based modelling techniques, in which the relationship between system properties is expressed with continuous mathematical equations or discrete modelling techniques that are based on individual units to model the heterogeneous microscopic elements such as individuals or cells. In this review, we survey these multi-scale methods and explore their application in systems biology.

Graphical abstract: Multi-scale modelling and simulation in systems biology

Article information

Article type
Review Article
Submitted
03 Aug 2010
Accepted
14 Dec 2010
First published
06 Jan 2011

Integr. Biol., 2011,3, 86-96

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