Issue 6, 2011
From the journal:

Natural Product Reports

Convergent strategies in biosynthesis

Tohru Dairi,*a   Tomohisa Kuzuyama,b   Makoto Nishiyamac  and  Isao Fujiid  

* Corresponding authors

a Faculty of Engineering and Graduate School of Engineering, Hokkaido University, Sapporo, Japan
E-mail: dairi@eng.hokudai.ac.jp
Fax: +81-11-706-7118
Tel: +81-11-706-7815

b Biotechnology Research Center, The University of Tokyo, Bunkyo-ku, Japan
E-mail: utkuz@mail.ecc.u-tokyo.ac.jp
Fax: +81-3-5841-8030
Tel: +81-3-5841-3073

c Biotechnology Research Center, The University of Tokyo, Bunkyo-ku, Japan
E-mail: umanis@mail.ecc.u-tokyo.ac.jp
Fax: +81-3-5841-8030
Tel: +81-3-5841-3074

d School of Pharmacy, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate, Japan
E-mail: ifujii@iwate-med.ac.jp
Fax: +81-19-698 1923
Tel: +81-19-651-5111

Abstract

Covering: 1999 to March 2010

This review article focuses on how nature sometimes solves the same problem in the biosynthesis of small molecules but using very different approaches. Four examples, involving isopentenyl diphosphate, menaquinone, lysine, and aromatic polyketides, are highlighted that represent different strategies in convergent metabolism.

Graphical abstract: Convergent strategies in biosynthesis

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Article information

DOI
https://doi.org/10.1039/C0NP00047G
Article type
Review Article
Submitted
24 Sep 2010
First published
06 May 2011

Nat. Prod. Rep., 2011,28, 1054-1086

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Convergent strategies in biosynthesis

T. Dairi, T. Kuzuyama, M. Nishiyama and I. Fujii, Nat. Prod. Rep., 2011, 28, 1054 DOI: 10.1039/C0NP00047G

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