Issue 12, 2011
From the journal:

Organic & Biomolecular Chemistry

Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues†

A. Jonathan Singh,a   Mina Razzak,b   Paul Teesdale-Spittle,a   Thomas N. Gaitanos,a   Anja Wilmes,a   Ian Paterson,b   Jonathan M. Goodman,b   John H. Millera  and  Peter T. Northcote*a  

* Corresponding authors

a Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand
E-mail: peter.northcote@vuw.ac.nz
Fax: +64 4 463 5237
Tel: +64 4 463 5960

b University Chemical Laboratory, University of Cambridge, Cambridge, United Kingdom

Abstract

Two new peloruside congeners (3 and 4) were isolated from wild and aquacultured collections of the New Zealand marine sponge Mycale hentscheli. Small-scale reactions on peloruside A (1) have been performed, which along with the isolation of 3 and 4, give further insight into the bioactive pharmacophore of 1.

Graphical abstract: Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0OB01127D
Article type
Paper
Submitted
06 Dec 2010
Accepted
21 Mar 2011
First published
23 Mar 2011

Org. Biomol. Chem., 2011,9, 4456-4466

Permissions

Request permissions

Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues

A. J. Singh, M. Razzak, P. Teesdale-Spittle, T. N. Gaitanos, A. Wilmes, I. Paterson, J. M. Goodman, J. H. Miller and P. T. Northcote, Org. Biomol. Chem., 2011, 9, 4456 DOI: 10.1039/C0OB01127D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements