Issue 2, 2011

Amine directed Pd(ii)-catalyzed C–H bond functionalization under ambient conditions

Abstract

Pd(II)-catalyzed C–H bond functionalizations that proceed under ambient conditions are a pivotal part of the future of chemical synthesis. Herein, an amine directed Pd(II)-catalyzed C–H bond functionalization strategy is described that generates a diversity of molecular frameworks via C–H carbonylation, C–H arylation and C–H amination. The new reactions work for a variety of substrates and are tolerant of delicate stereogenic centres and functionality. Furthermore, the new reactions can be sequenced to generate complex architectures from simple building blocks via iterative Pd(II)-catalyzed C–H bond functionalization.

Graphical abstract: Amine directed Pd(ii)-catalyzed C–H bond functionalization under ambient conditions

Supplementary files

Article information

Article type
Edge Article
Submitted
10 Jul 2010
Accepted
24 Sep 2010
First published
15 Oct 2010

Chem. Sci., 2011,2, 312-315

Amine directed Pd(II)-catalyzed C–H bond functionalization under ambient conditions

B. Haffemayer, M. Gulias and M. J. Gaunt, Chem. Sci., 2011, 2, 312 DOI: 10.1039/C0SC00367K

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