Issue 3, 2011

Nanoparticles with targeting, triggered release, and imaging functionality for cancer applications

Abstract

The tendency for nanoparticles to accumulate in tumor regions as a result of the enhanced permeability and retention effect has proven to be an advantageous feature for delivery of anti-cancer therapeutics and contrast agents for cancer detection. However, efficient drug delivery is dependent on nanoparticle stability in the circulation, accumulation and penetration into tumor tissues, and release of drugs to their sites of activity. Nanoparticles can be engineered bearing multiple functionalities to achieve optimal therapeutic and diagnostic effects. This review examines functionalities engineered into nanoparticles, including active targeting, triggered release of contents, and imaging capabilities.

Graphical abstract: Nanoparticles with targeting, triggered release, and imaging functionality for cancer applications

Article information

Article type
Review Article
Submitted
15 Jun 2010
Accepted
08 Sep 2010
First published
13 Oct 2010

Soft Matter, 2011,7, 839-856

Nanoparticles with targeting, triggered release, and imaging functionality for cancer applications

K. Loomis, K. McNeeley and R. V. Bellamkonda, Soft Matter, 2011, 7, 839 DOI: 10.1039/C0SM00534G

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