Issue 3, 2011

Mobility of fluorescently labeled polymer micelles in living cells

Abstract

Stabilized fluorescent polymeric micelles were made that are spontaneously taken up into the cytoplasm of human cells. The mobility of these micelles in living cells was probed on a molecular level for the first time with FCS. Importantly, the present micelles do not interact with proteins, membranes or cellular organelles. This system provides a new nanotechnological tool which is biocompatible, versatile and easy to use, especially since after further chemical modification, they could be targeted to specific subcellular locations.

Graphical abstract: Mobility of fluorescently labeled polymer micelles in living cells

Article information

Article type
Paper
Submitted
18 Aug 2010
Accepted
27 Nov 2010
First published
20 Dec 2010

Soft Matter, 2011,7, 1214-1218

Mobility of fluorescently labeled polymer micelles in living cells

F. Li, A. H. Westphal, A. T. M. Marcelis, E. J. R. Sudhölter, M. A. Cohen Stuart and F. A. M. Leermakers, Soft Matter, 2011, 7, 1214 DOI: 10.1039/C0SM00835D

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