Issue 12, 2011
From the journal:

Chemical Communications

Surface-tethered protein switches†

Maya Zayats,a   Manu Kanwar,b   Marc Ostermeier*b  and  Peter C. Searson*ab  

* Corresponding authors

a Department of Materials Science and Engineering, Johns Hopkins University, Baltimore
E-mail: searson@jhu.edu

b Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore
E-mail: oster@jhu.edu

Abstract

Protein switches are engineered fusion proteins with an input domain that recognizes and responds to an input signal and an output domain whose function is regulated by the state of the input domain. Here we demonstrate a fully functional surface tethered protein switch that offers a potential route to a universal biosensing platform.

Graphical abstract: Surface-tethered protein switches

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Article information

DOI
https://doi.org/10.1039/C1CC10146C
Article type
Communication
Submitted
07 Jan 2011
Accepted
02 Feb 2011
First published
18 Feb 2011

Chem. Commun., 2011,47, 3398-3400

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Surface-tethered protein switches

M. Zayats, M. Kanwar, M. Ostermeier and P. C. Searson, Chem. Commun., 2011, 47, 3398 DOI: 10.1039/C1CC10146C

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