Issue 38, 2011

Time-dependent intermolecular interaction during protein reactions

Abstract

A recently developed method to monitor reaction kinetics of intermolecular interaction is presented in this perspective. This method is based on time-dependent diffusion coefficient measurements using the pulsed laser induced transient grating technique. Using this method, time dependent biomolecular interactions, such as transient association and dissociation reactions in solution, have been successfully detected in real time. The principles and particular applications are described. In particular, unique features of this time-dependent diffusion coefficient method are emphasized by comparison with other techniques.

Graphical abstract: Time-dependent intermolecular interaction during protein reactions

Article information

Article type
Perspective
Submitted
09 Jun 2011
Accepted
15 Aug 2011
First published
05 Sep 2011

Phys. Chem. Chem. Phys., 2011,13, 16928-16940

Time-dependent intermolecular interaction during protein reactions

M. Terazima, Phys. Chem. Chem. Phys., 2011, 13, 16928 DOI: 10.1039/C1CP21868A

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